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Key findings include: Achilles tendon healing : In rat models, BPC-157 at 10 g/kg accelerated healing by promoting F-actin formation and tendon fibroblast migration within 7-14 days post-injury Dose-response relationship : Effects observed across a range from 1 g/kg to 100 g/kg, with maximal effect plateau at 10 g/kg in most models Mechanism specificity : Healing acceleration involves upregulation of VEGF receptor 2 and increased endothelial cell density at injury sites Chang et al

Why The Effect Is Synergistic, Not Additive Because GHRH and GHRP act on distinct receptors that converge on GH release through partly independent second-messenger systems, their combined effect is larger than additive

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